Table 2.
Mixed effects cox model of wildfire smoke-day exposure during post-partum trimester at the 25% exposure threshold, in all eligible children and stratified by sex. P1 and P2 periods correspond to 0–12 and 13–24 weeks, respectively. Models are adjusted for birth-season, birthyear and, where applicable, sex, with a random intercept for MSA. All exposures are the average weekly number of smoke-days in the given post-partum period. RX = prescribed medication claim; “25% exposure threshold” refers to population-weighted percentage of zip codes, here 25%, within an MSA required to experience a smoke-day, in order to assign a smoke-day to the MSA
| All children | Male children | Female children | Likelihood ratio test p-value | |||||
|---|---|---|---|---|---|---|---|---|
| Cases | HR (95% CI) | Cases | HR (95% CI) | Cases | HR (95% CI) | |||
| Upper respiratory RX | P1 | 2,437 | 1.094 (1.005, 1.191) | 1,380 | 1.055 (0.940, 1.185) | 1,057 | 1.123 (0.994, 1.270) | 0.11 |
| P2 | 2,367 | 1.108 (1.016, 1.209) | 1,336 | 1.128 (1.004, 1.266) | 1,031 | 1.072 (0.942, 1.220) | 0.48 | |
| Lower respiratory RX | P1 | 31,785 | 1.007 (0.983, 1.031) | 18,462 | 1.013 (0.982, 1.045) | 13,323 | 0.992 (0.955, 1.030) | 0.02 |
| P2 | 25,762 | 0.980 (0.955, 1.007) | 14,727 | 0.971 (0.938, 1.005) | 11,035 | 0.987 (0.947, 1.029) | 0.42 | |
| Systemic Anti-inflammatory RX | P1 | 23,496 | 1.001 (0.975, 1.028) | 13,909 | 0.995 (0.961, 1.030) | 9,587 | 1.008 (0.966, 1.051) | 0.74 |
| P2 | 21,067 | 0.996 (0.969, 1.025) | 12,351 | 1.004 (0.968, 1.042) | 8,716 | 0.980 (0.938, 1.025) | 0.34 | |