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Chemical structures of representative NS4B inhibitors.
| Compound | Virus | EC50 (μM) | Structure | Reference |
|---|---|---|---|---|
| NITD-618 | DENV-1 | 1.5 |
|
(Xie et al., 2011) |
| DENV-2 | 1.0 | |||
| DENV-3 | 1.6 | |||
| DENV-4 | 4.1 | |||
| Compound 14a | DENV-1 | >1 |
|
(Wang et al., 2015) |
| DENV-2 | 0.042 | |||
| DENV-3 | 0.032 | |||
| DENV-4 | >1 | |||
| NITD-688 | DENV-1 | 0.038 |
|
(Moquin et al., 2021) |
| DENV-2 | 0.008 | |||
| DENV-3 | 0.008 | |||
| DENV-4 | 0.012 | |||
| JNJ-A07 | DENV-1 | <0.0003 |
|
(Kaptein et al., 2021) |
| DENV-2 | <0.004 | |||
| DENV-3 | <0.001 | |||
| DENV-4 | <0.006 | |||
| BDAA | YFV | 0.21 |
|
(Guo et al., 2016) |
