TABLE 2.
Six out of the top 15 metabolic sets are significantly affected under Pi starvation
| Pathwaya | Match statusb | P value | −log (P)c | Impactd |
|---|---|---|---|---|
| Purine metabolism | 17/62 | 0.0000056885 | 5.245 | 0.43543 |
| Pyrimidine metabolism | 9/34 | 0.0016028 | 2.7951 | 0.47488 |
| Glycolysis or gluconeogenesis | 6/24 | 0.013697 | 1.8634 | 0.41811 |
| Nicotinate and nicotinamide metabolism | 4/12 | 0.015489 | 1.81 | 0.50185 |
| Cysteine and methionine metabolism | 8/41 | 0.02079 | 1.6822 | 0.21078 |
| Citrate cycle (TCA cycle) | 5/20 | 0.024305 | 1.6143 | 0.2306 |
| Methane metabolism | 5/23 | 0.042866 | 1.3679 | 0.32774 |
| Lysine biosynthesis | 4/16 | 0.043511 | 1.3614 | 0.0 |
| Glycine, serine, and threonine metabolism | 6/32 | 0.052435 | 1.2804 | 0.30324 |
| Arginine biosynthesis | 4/18 | 0.064018 | 1.1937 | 0.14819 |
| Pentose phosphate pathway | 4/18 | 0.064018 | 1.1937 | 0.52896 |
| Glyoxylate and dicarboxylate metabolism | 5/26 | 0.068182 | 1.1663 | 0.26506 |
| Cyanoamino acid metabolism | 2/8 | 0.14937 | 0.82572 | 0.0 |
| Synthesis and degradation of ketone bodies | 1/3 | 0.23995 | 0.61987 | 0.0 |
| Beta-alanine metabolism | 2/11 | 0.24839 | 0.60487 | 0.0 |
a
The data correspond to Fig. 4B; bold font indicates significant pathways.
b
(Number of significant metabolites)/(total number of metabolites) in given pathway.
c
The top 15 metabolic pathways were ranked based on P value. The metabolic pathways with a −log (P) value of >1.5 were considered significantly altered in this analysis.
d
The impact value was calculated by pathway topology analysis.