TABLE 3.

Six out of the top 15 pathways emerging from metabolite set enrichment analysis are significant

Metabolite seta	Total	Hits	Expected	P valueb
Pyrimidine metabolism	39	7	1.05	0.0000494
Nicotinate and nicotinamide metabolism	15	4	0.404	0.0005
Glycolysis/gluconeogenesis	26	4	0.7	0.00441
Purine metabolism	65	6	1.75	0.00666
Pantothenate and CoA biosynthesis	19	3	0.512	0.013
Biotin metabolism	10	2	0.269	0.0278
Neomycin, kanamycin, and gentamicin biosynthesis	2	1	0.0539	0.0532
Butanoate metabolism	15	2	0.404	0.0596
Tryptophan metabolism	41	3	1.1	0.0954
Citrate cycle (TCA cycle)	20	2	0.539	0.0991
Fructose and mannose metabolism	20	2	0.539	0.0991
β-Alanine metabolism	21	2	0.566	0.108
Pentose phosphate pathway	22	2	0.593	0.117
Alanine, aspartate, and glutamate metabolism	28	2	0.754	0.173
Inositol phosphate metabolism	30	2	0.808	0.192

^aThe data correspond to Fig. 8B; bold font indicates significant pathways.

^bThe top 15 metabolite sets were ranked based on P value. Metabolic sets with a P value of <0.05 were considered significantly altered.