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Model for the SigS-SroAB regulatory circuit. In response to the DNA-damaging agent MMS, SigS is activated (through an unknown mechanism). SigS acts to stimulate sroAB expression. SroA and SroB interact with each other under normal circumstances. In response to an unidentified internal or external signal, SroA-SroB association is inhibited through a mechanism that is unclear. Then, free SroA promotes SigS accumulation through inhibition of RNases that promote SigS transcript degradation.
