TABLE 3.

A summary of the risk of bias assessment of all eligible studies.

References (publication year)	Random sequence generation (selection bias)	Allocation concealment (selection bias)	Blinding of participants and personnel (performance bias)	Blinding of outcome assessment (detection bias)	Incomplete outcome data (attrition bias)	Selective reporting (reporting bias)	Other bias
Mizugaki et al. (2015)	?	–	–	–	+	+	?
Huang et al. (2020)	?	?	?	?	+	+	?
Sebastian et al. (2019)	?	?	?	?	+	+	?
Novello et al. (2014a)	?	+	?	?	+	+	?
Cappuzzo et al. (2006)	?	?	?	?	+	?	–
Srinivasa et al. (2020)	?	?	?	?	+	+	?
Yoshioka et al. (2017)	+	–	–	–	+	+	?
Johnson et al. (2013)	+	+	+	+	+	+	+
EU Clinical Trials Register. (2011)	?	+	?	?	+	+	?
Gridelli et al. (2001)	+	+	?	?	+	+	?
Martoni et al. (1991)	?	?	–	–	+	+	?
Sequist et al. (2013), Boehringer Ingelheim (2018a), Wu et al. (2018)	+	+	–	–	+	+	?
Boehringer Ingelheim (2018b)	+	+	–	–	+	+	?
Boehringer Ingelheim (2020)	+	+	–	–	+	+	?
Hida et al. (2017)	+	–	–	–	+	+	?
Berghmans et al. (2013)	+	+	?	?	+	+	?
GlaxoSmithKline (2014)	+	+	+	+	+	+	+
Martoni et al. (1999)	+	+	–	–	+	+	?
Reck et al. (2015)	?	?	+	?	+	+	?
Saito et al. (2003)	?	?	?	?	+	+	?
Barlesi et al. (2018)	+	+	–	?	+	+	?
Camidge et al. (2018)	+	?	?	?	+	+	?
Wachters et al. (2004)	+	?	?	?	+	+	?
Shaw et al. (2013)	–	–	–	–	+	+	?
Solomon et al. (2014)	–	–	–	–	+	+	?
Bonomi et al. (2000)	+	?	?	?	+	+	?
Zatloukal et al. (2004)	+	?	–	–	+	+	?
Zarogoulidis et al. (2013)	+	?	?	?	+	+	?
Koch et al. (2011)	+	+	+	+	+	+	+
Bi et al. (2019)	+	+	–	–	+	+	?
Herbst et al. (2011)	+	+	+	+	+	+	+
Seto et al. (2014)	+	+	–	+	+	+	?
(National Cancer Institute (NCI), 2019)	+	+	+	+	+	+	+
Kato et al. (2018)	+	+	–	+	+	+	?
Stathopoulos et al. (2004)	+	–	?	?	+	+	?
Valdivieso et al. (1984)	+	?	?	?	+	+	?
Baggstrom et al. (2017a)	+	–	?	?	+	+	?
Paz-Ares et al. (2015)	+	–	+	?	+	+	?
Novello et al. (2014b)	+	+	+	?	+	+	?
Akamatsu et al. (2018)	+	+	–	–	+	+	?
Kosmidis et al. (2008)	+	+	–	?	+	+	?
Reinmuth et al. (2019)	+	+	+	?	+	+	?
Blumenschein et al. (2010)	?	?	–	–	+	+	?
Choy et al. (2013)	+	?	–	–	+	+	?
William et al. (2007)	?	?	–	–	+	+	?
Chang et al. (1993)	+	?	?	?	+	+	?
Kubota et al. (2017)	+	–	+	+	+	+	?
Zinner et al. (2015)	+	–	?	?	+	+	?
Heigener et al. (2013)	+	?	–	–	+	+	?
Jie Wang et al. (2018)	+	?	?	?	+	+	?
Eli Lilly and Company (2019a)	+	+	+	+	+	+	+
Douillard (2004)	+	?	+	?	+	+	?
Butts et al. (2007)	+	–	–	+	+	+	?
Fukuda et al. (2019)	+	–	?	?	+	?	?
Passardi et al. (2008)	+	?	?	?	+	?	?
Gatzemeier et al. (2004)	+	?	–	?	+	?	?
Park et al. (2017)	+	?	?	?	+	?	?
Movsas et al. (2005)	+	+	+	+	+	+	+
Jänne et al. (2014)	+	?	?	?	+	+	?
Groen et al. (2011)	+	?	?	?	+	?	?
Currow et al. (2017)	+	?	+	+	+	?	?
Langer et al. (2017)	+	?	?	?	+	?	?
Kotsakis et al. (2015)	+	?	–	–	+	?	?
Eli Lilly and Company (2015)	+	+	+	+	+	+	+
GlaxoSmithKline (2019)	+	+	–	+	+	+	+
Lara et al. (2016)	+	?	–	?	+	?	?
Wu et al. (2020)	+	+	+	+	+	?	?
Umsawasdi et al. (1989)	+	?	–	?	+	?	?
Cortot et al. (2020)	+	+	–	?	+	+	?
AstraZeneca (2021)	+	+	+	+	+	+	+
Johnson et al. (2004)	+	+	–	+	+	+	?
Eli Lilly and Company (2022)	+	+	+	+	+	+	+
Eli Lilly and Company (2021)	+	+	+	+	+	+	+
Eli Lilly and Company (2019b)	+	+	+	+	+	+	+