. 2023 Jun 26;15(1):2221758. doi: 10.1080/19490976.2023.2221758

Table 4.

Effects of a combination of Lactobacillus spp., Bifidobacterium spp., and Saccharomyces boulardii on days to reach full feed.

Study	Country	Treatment	Sample size		Average days to reach full feed		Registered	Sequence generation & Allocation concealment	Data collectors/outcome assessors blinded	Year last enrolled participant	Primary Outcome(s)	Comments
Study	Country	Treatment	Treatment	Control	Treatment	Control	Registered	Sequence generation & Allocation concealment	Data collectors/outcome assessors blinded	Year last enrolled participant	Primary Outcome(s)	Comments
Hariharan et al.¹³⁸	India	L. acidophilus, B. bifidum, S. boulardii	93	103	23.6*	32.4*	No	UTD randomization method	UTD	UTD	Time to achieve oral feeds	Abstract only
Arora et al.¹³⁹	India	L. rhamnosus, L. acidophilus, B. longum, S. boulardii	75	75	8.53	10.7	No	UTD randomization method	UTD	2016	NEC	Days to reach full feed stated as secondary outcome
Shashidhar et al.¹³⁷	India	L. rhamnosus, L. acidophilus, B. longum, S. boulardii	48	48	11.2	12.7	Yes (CTRI/2012/08/002853)^¶	Low risk	Low risk	2013	Time to full enteral feeding

NA = not available.

UTD = unable to be determined based on information provided.

*Difference in outcome between treatment and control arms was significant.