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Canonical pathway of NF-κB activation. Several inflammatory signals, such as pathogen-associated molecular patterns (PAMPS) and pro-inflammatory cytokines, activate canonical signaling through a complex containing IKK1/2 and NEMO. IKK1/2-mediated IκBs phosphorylation is a signal for ubiquitination and subsequent proteasomal degradation. Free NFκB dimers enter the nucleus, where they bind consensus DNA sequences and regulate the transcription of target genes.
