Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Iron accumulation is important in the pathogenesis of PD. Dysregulation of CP, IRP2, Nrf2 and FtMt alters brain iron levels, which, in turn, affects the expression of iron metabolism proteins. Iron overload and increased ROS aggravate the development and progression of PD, and their interactions with α-synuclein, dopamine, neuromelanin, Parkin and LRRK2 contribute to dopaminergic neuronal cell death and the onset of PD.
