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. 2023 May 26;11(6):1544. doi: 10.3390/biomedicines11061544

Figure 3.

Figure 3

Laser scanning confocal microscopy. Serial optical sections from the top to the bottom of M14WT/HUVEC cell co-cultures after 5 h of interaction. (a) Actin-labelled HUVEC cell. (b) Merged signal of clustered M14 WT cells (red signal, arrow heads) undergoing transcellular invasion. HUVEC F-actin is assembled into a ring-like array around the circumference of the invasion pore (green signal, arrow) that seems to encapsulate the invading cancer cells. The yellow signal represents the co-localisation of HUVEC and melanoma cell structures. Bar: 100 µm.