Table 3.
2-DG-induced gene expression changes in the Fus1 KO mouse cochlea (KEGG analysis). This table illustrates changes in the number of pathways in different biological categories that were upregulated and downregulated in the cochleae of untreated vs. 2-deoxy-D-glucose (2-DG)-treated 7-month-old Fus1 KO mice, as revealed by KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis.
| Biological Pathway Category | KO Control ⬆ | KO 2-DG ⬆ | KO Control ⬇ | KO 2-DG ⬇ |
|---|---|---|---|---|
| Neural response | 1 | 1 | 1 | 1 |
| Metabolism and associated diseases | 9 | 1 | 1 | 1 |
| Immune system and associated diseases | 1 | 4 | 17 | 8 |
| Cell cycle | 0 | 0 | 1 | 1 |
| Signal transduction | 0 | 0 | 2 | 1 |
| Cell adhesion | 0 | 1 | 1 | 0 |
Highlighted in grey are pathway categories that were substantially altered by 2-DG treatment. ⬆= upregulation, ⬇= downregulation.