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Mechanism of action of gabapentin in the locus coeruleus. GLT-1: glutamate transporter 1. α2δ: subunit of voltage-gated Ca2+ channels (VGCCs). Glu: glutamate. GABA: neurotransmitter gamma-aminobutyric acid. Gaba-A: GABA receptor A. AMPA: (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) ionotropic transmembrane receptor for glutamate. NA: noradrenalin.
