Table 1.

Summary of the different studies on oral gabapentin use in canine patients.

Medical Condition	Therapeutic Regimen	Clinical Endpoint	Outcome	Study Type	Reference
Refractory idiopathic epilepsy	An amount of 35–50 mg/kg every 24 h, divided in three times for four months as adjunctive therapy	To assess a change in seizure activity	Beneficial in increasing the interictal period	Prospective clinical trial (n = 17)	[10]
Refractory idiopathic epilepsy	An amount of 10 mg/kg every 8 h for a minimum three months as adjunctive therapy	To assess a change in seizure activity	Beneficial in reducing seizures episodes	Prospective clinical trial (n = 11)	[11]
Refractory psychomotor seizures	An amount of 10 mg/kg every 8 h	To assess a change in seizure activity	Beneficial in resetting seizures episodes	Case report (n = 1)	[68]
Postoperative pain after intervertebral disc surgery	An amount of 10 mg/kg every 12 h, starting from 2 h before anaesthesia to five days after surgery, in addition to opioid analgesia	To assess the effect of adjunctive gabapentin after surgery	Nonbeneficial	Randomized, placebo-controlled, masked trial (n = 63)	[57]
Neurogenic pain from syringomyelia	An amount of 10 mg/kg every 8–12 h, long-term therapy depending on clinical response	Medical treatment for neurogenic pain	Beneficial	Case report (n = 2)	[39]
Pain from Chiari-like malformation and syringomyelia	An amount of 11.5 ± 2.5 mg/kg every 8 h for six weeks with carprofen	Medical treatment for neurogenic pain	Beneficial	Cross-over, masked trial (n = 40)	[12]
Chronic neuropathic pain	An amount of 10 mg/kg every 8 h for seven days alone or in combination with meloxicam every 24 h	Medical treatment for neurogenic pain	Beneficial	Randomized, cross-over, placebo-controlled, partially masked trial (n = 31)	[13]
Postoperative pain after amputation of a forelimb	An amount of 5–10 mg/kg every 12 h, from one day before surgery to three days after in a multimodal analgesic regimen	To assess postoperative pain reduction	Nonbeneficial	Randomized, placebo-controlled, masked trial (n = 30)	[56]
Postoperative pain after mastectomy	An amount of 10 mg/kg prior to surgery and every 12 h for three days after surgery, as adjunctive therapy	To assess postoperative pain reduction	Nonbeneficial in reducing pain, beneficial in reducing the requirement of rescue analgesia after surgery	Randomized, placebo-controlled, masked trial (n = 20)	[58]
Osteoarthritis	An amount of 10 mg/kg every 12 h (first week), 5 mg/kg every 12 h (rest of the period), 12 weeks in a multimodal analgesic regimen	Medical treatment for neurogenic pain and quality of life improvement	Beneficial in association with anti-inflammatory drugs, cannabidiol, and amitriptyline	Prospective, randomized clinical trial (n = 21)	[14]
Healthy dogs	An amount of 50 mg/kg 2 h before anaesthesia in single administration	To assess intraoperative ocular pressure changes	Beneficial in attenuating intubation-related intraocular pressure increase	Randomized, placebo-controlled, masked trial (n = 20)	[73]
Healthy dogs	An amount of 10 mg/kg every 8 h for three days	To assess intraocular pressure, tears production and film stability, pupillary diameter, and corneal sensitivity variation	Nonbeneficial	Randomized, cross-over, masked trial (n = 9)	[74]
Healthy dogs	An amount of 20 mg/kg 2 h before anaesthesia and after seven days	Evaluation of gabapentin effect in premedication on the MAC of isoflurane	Beneficial in reducing the MAC	Randomized, cross-over, masked trial (n = 6)	[75]
Storm phobia and anxiety	An amount of 25–30 mg/kg 90 min before the exposure, single dose	Reduction in fear responses	Beneficial	Cross-over, placebo-controlled, double-blinded trial (n = 18)	[15]
Anxiety and fear	An amount of 50 mg/kg, single dose 2 h before the visit	To create fear-free veterinary visits	Beneficial	Randomized, cross-over, placebo-controlled, double-blinded trial (n = 22)	[16]