Table 2.

Summary of the different studies on oral gabapentin use in feline patients.

Medical Condition	Therapeutic Regimen	Clinical Endpoint	Outcome	Study Type	Reference
Major trauma from road traffic accident	An amount of 10 mg/kg every 8 h for two weeks in a multimodal analgesic regimen	Managing chronic neuropathic pain	Beneficial	Case report (n = 2)	[42]
Musculoskeletal injuries and trauma	An amount of 6.5 mg/kg every 12 h up to 12 months initially as adjunctive therapy and then as single analgesic at home	Managing chronic neuropathic pain	Beneficial	Case report (n = 3)	[41]
Postoperative pain after ovariohysterectomy	An amount of 50 mg, administered 12 h and 1 h before surgery in combination with buprenorphine	Managing postoperative pain	Beneficial	Randomized, placebo-controlled, masked trial (n = 52)	[18]
Osteoarthritis	An amount of 10 mg/kg every 12 h for two weeks	Managing chronic pain	Beneficial, sedation as unique side effect	Randomized, cross-over, placebo-controlled, masked trial (n = 20)	[40]
Osteoarthritis and dental disease	An amount of 10 mg/kg every 8 h for five days (transdermal route)	Managing chronic pain	Beneficial	Prospective clinical trial (n = 15)	[78]
Discospondylitis-related chronic neuropathic pain	Not reported	Managing chronic neuropathic pain	Not reported	Retrospective clinical trial (n = 17)	[85]
Thermal antinociceptive threshold test	Amounts of 5, 10, and 30 mg/kg, single administration	Determination of the thermal antinociceptive effect of various single doses	Non beneficial	Randomized, cross-over, placebo-controlled, masked trial (n = 6)	[79]
Anxiety and fear	An amount of 9.2–47.6 mg/kg, single administration	To create a fear-free veterinary visits	Beneficial	Randomized, placebo-controlled, double-blinded trial (n = 53)	[19]
Anxiety and fear	An amount of 13.0–29.4 mg/kg, single administration 90 min prior to placing the cat into the carrier	To create a fear-free veterinary visits	Beneficial	Randomized, cross-over, placebo-controlled, masked trial (n = 20)	[20]
Anxiety and fear	An amount of 100 mg/cat ≤ 4 kg, 150 mg/cat ≥ 4.1 kg, single administration 30 min before the visit	To create a fear-free veterinary visits and provoke mild sedation to execute an hemodynamical and cardiological evaluation	Beneficial	Randomized, cross-over, placebo-controlled, double-blinded trial (n = 10)	[22]
Anxiety and fear	An amount of 20 mg/kg, single administration 1 h prior to leaving home	To evaluate the efficacy of gabapentin as an anxiolytic in hyperthyroid patients	Beneficial	Randomized, placebo-controlled, double-blinded trial (n = 10)	[21]
Healthy cats undergoing ovariectomy	An amount of 5 mg/kg, two administrations after surgery, during an 8 h observation period	Evaluation of the appetite-stimulating effect	Beneficial	Randomized, placebo-controlled, double-blinded trial (n = 60)	[17]