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. 2023 May 29;12(6):978. doi: 10.3390/antibiotics12060978

Table 3.

Toxicities related to the use of systemic antibiotics (based on the prescribing information).

Types of Toxicity Antibiotic Drugs
Liver toxicity

  • Clindamycin (common);

  • Ertapenem (uncommon);

  • Macrolides (uncommon);

  • Rifampicin (unknown);

  • Tetracyclines (unknown);

  • Metronidazole (uncommon);

  • Linezolid (common).
Renal toxicity

  • Clindamycin (common);

  • Ertapenem (uncommon);

  • Macrolides (uncommon);

  • Rifampicin (unknown);

  • Oxofloxacin (uncommon);

  • Metronidazole (uncommon);

  • Linezolid (common).
Gastrointestinal toxicity

  • Clindamycin (common);

  • Ertapenem (common);

  • Macrolides (very common);

  • Rifampicin (common);

  • Oxofloxacin (common);

  • Tetracyclines (common);

  • Dalbavancin (common);

  • Metronidazole (unknown);

  • Linezolid (common).
Nervous system toxicity

  • Clindamycin (uncommon);

  • Ertapenem (common);

  • Macrolides (common);

  • Oxofloxacin (uncommon);

  • Rifampicin (common);

  • Tetracyclines (common);

  • Dalbavancin (common);

  • Dalbavancin (uncommon);

  • Linezolid (common).
Hemolymphopoietic toxicity

  • Clindamycin (unknown);

  • Ertapenem (uncommon);

  • Macrolides (uncommon);

  • Rifampicin (unknown);

  • Oxofloxacin (uncommon);

  • Tetracyclines (unknown);

  • Dalbavancin (uncommon);

  • Metronidazole (uncommon);

  • Linezolid (common).
Vascular toxicity

  • Clindamycin (common);

  • Ertapenem (common);

  • Rifampicin (unknown);

  • Oxofloxacin (rare);

  • Dalbavancin (uncommon);

  • Linezolid (common).
Cardiac toxicity

  • Clindamycin (uncommon);

  • Ertapenem (uncommon);

  • Macrolides (uncommon);

  • Oxofloxacin (rare).
Cutaneous and subcutaneous toxicity

  • Clindamycin (common);

  • Ertapenem (common);

  • Macrolides (uncommon);

  • Rifampicin (unknown);

  • Oxofloxacin (common);

  • tetracyclines (unknown);

  • Dalbavancin (uncommon);

  • Metronidazole (uncommon);

  • Linezolid (common).
Infections

  • Clindamycin (unknown);

  • Ertapenem (uncommon);

  • Macrolides (uncommon);

  • Rifampicin (unknown);

  • Oxofloxacin (uncommon);

  • Dalbavancin (uncommon);

  • Metronidazole (common);

  • Linezolid (common).
Ototoxicity

  • Macrolides (uncommon);

  • Linezolid (uncommon).
Musculoskeletal toxicity

  • Macrolides (uncommon);

  • Rifampicin (unknown);

  • Oxofloxacin (uncommon);

  • Metronidazole (uncommon).