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. 2023 Apr 3;29:43. doi: 10.1186/s10020-023-00640-7

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Overview of the KEGG “Huntington’s Disease Signaling Pathway” with new direct miR-34a-5p target genes. A Impact of miR-34a deregulation on the subcategories “glutamatergic synapse”, “calcium signaling”, “transcriptional activation”, “mitochondrial dysfunction”, “ER stress” and “apoptosis”. Direct target genes of miR-34a-5p are marked in green. All marked target genes were identified by our group. Target genes with no asterisk were identified in this study. Target genes with asterisks were identified in recent studies as indicated in the diagram (Kern et al. 2021; Diener et al. 2018; Krammes et al. 2020). B Impact of miR-34a deregulation on the subcategories “endocytosis”, “vesicular transport”, “transcriptional repression”, “respiration”, “protein folding” and “apoptosis”. Direct target genes of miR-34a-5p are marked in green. All marked target genes were identified by our group. Target genes with no asterisk were identified in this study. Target genes with one asterisk were identified in a recent study as indicated in the diagram (Kern et al. 2021)