Figure 4.

Transcriptional regulation of ACSL4. ACSL4 expression can be regulated by multiple transcription factors and non-coding RNA molecules (such as lncRNA and miRNA). Additionally, ACSL4 can undergo various post-translational modifications, including ubiquitination (Ub), phosphorylation (P), acetylation (ac), and O-GlcNAcylation (O-Glc), as well as engage in protein–protein interactions. These regulatory mechanisms play a crucial role in modulating cell death and various biological functions.