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ACSL4 in autophagy. ACSL4 can regulate the autophagy process through different mechanisms. It can inhibit autophagy by promoting mTOR expression or binding to V-ATPase. On the other hand, Faa1, located in the phagophore, promotes de novo synthesis of fatty acids, and extracellular SQSTM1-dependent ACSL4 expression promotes autophagy.
