Table 1.

Observations from studies concerning MMP8 −799 C > T (rs11225395) +17 C/G (rs2155052) and −381A/G (rs11225395) polymorphisms in periodontitis.

Polymorphism in MMP8	Population	Disease	Patients/Controls	Observation
−799 (C > T)	Taiwan	AgP + CP	96 + 361/106	Increased risk for AgP (p = 0.04) and CP (p = 0.007) in carriers of T allele [44].
−799 (C > T)				No differences in allele (p = 0.06) and genotype (p = 0.280 distributions. No associations with particular periodontal pathogen [45]
	Czech	CP	341/278
+17 (C > G)	Czech	CP	341/278	No differences in allele (p = 0.38) and genotype (p = 0.09) distributions. No associations with particular periodontal pathogen [45]
−799C>T/+17C > G haplotypes	Czech	CP	341/278	-799T/+17C haplotype is associated with 1.273-fold risk of CP (p = 0.038) [45]
−799 (C > T)	Turkish	GAgP	100/267	T allele (p < 0.0001) and T allele genotypes (CT + TT, p < 0.0001) were more common in GAgP determining 2.878-; 6.76-fold higher risk of GAgP compared to the wild C allele and CC genotype [18].
+17 (C > G)	Turkish	GAgP	100/267	No differences in allele (p = 0.290) and genotype (p = 0.581) distributions [18]
−381 (A > G)	Turkish	GAgP	100/267	G allele (p = 0.027) and G allele genotypes (AG + GG, p = 0.015) were less common in GAgP determining 1.5- and 2.27-fold lower risk of GAgP (OR = 0.664 and OR = 0.44) compared to the wild A allele and AA genotype [18]

CP—chronic periodontitis; AgP—aggressive periodontitis; GAgP—generalized aggressive periodontitis.