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. 2023 Jun 13;12(6):1267. doi: 10.3390/antiox12061267

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of EEVP on Th1 and Th2 cytokine secretion by cultured splenocytes generated from NC/Nga mice. (A) Interferon (IFN)-γ, (B) interleukin (IL)-4, (C) IL-5, and (D) IL-13 levels were determined in culture supernatant of splenocytes incubated on anti-CD3 antibody-coating plate for 48 h with dexamethasone and EEVP. Normal: NC/Nga normal control; Control: DNCB-induced AD control group; Dexa: DNCB + 3 mg/kg dexamethasone; EEVP 200: DNCB + 200 mg/kg of EEVP. Values are expressed as mean ± standard error of the mean (n = 6). # p < 0.05, ## p < 0.01, and ### p < 0.001 vs. Normal; * p < 0.05, ** p < 0.01, and *** p < 0.001 vs. Control as determined using one-way analysis of variance followed by multiple comparison tests.