Table 1:
Baseline anthropometric, endocrine and metabolic characteristics of study subjects
| Variables | PCOS (n=23) | Control (n=23) | p-value | p-value (Age Adjusted) |
|---|---|---|---|---|
| Age (years) | 26.7±1. 0 | 34.3±1.6 | 0.001 | N/A |
| Race (n and %) | ||||
| African-American | 2 (8.7) | 6 (26.1) | 0.145 | N/A |
| Asian-American | 3 (13. 0) | 4 (17.4) | 0.707 | N/A |
| Hispanic White | 11 (47.8) | 6 (26.1) | 0.222 | N/A |
| Non-Hispanic White | 7 (30.4) | 7 (30.4) | 0.999 | N/A |
| Anthropometric Measures | ||||
| Body mass index (kg/m 2 ) | 30.3±0.9 | 28.1±1.2 | 0.139 | 0.130 |
| WHR | 0.89±0.02 | 0.87±0.03 | 0.506 | 0.601 |
| Androgenism Measures | ||||
| mF-G score | 8.1±1.0 | 1.3±0.4 | 0.001 | 0.001 |
| Free Testosterone (pmol/L) a | 16.4 (6.6–38.2) | 7.6 (3.1–19.4) | 0.001 | 0.005 |
| Total Testosterone (nmol/L) a | 1.5 (0.7–3.1) | 0.9 (0.5–1.3) | 0.001 | 0.026 |
| DHEAS (umol/L) | 8.2±0.4 | 4.4±0.7 | 0.001 | 0.004 |
| Metabolic function (Basal State) | ||||
| Fasting glucose(mmol/L) a | 5.0 (3.8–5.9) | 4.9 (2.8–5.9) | 0.46 | 0.149 |
| Fasting Insulin (pmol/L) a | 91.1 (7.2–991.2) | 58.1 (14.4–129.2) | 0.16 | 0.277 |
| HOMA IR a | 2.8 (0.2–29.45) | 1.7 (0.3–3.5) | 0.134 | 0.085 |
| HOMA-β% a | 56.5 (17–483) | 27.9 (7.1–63.5) | 0.042 | 0.044 |
| Glucose Transporters mRNA levels | ||||
| GLUT-1 | 6.1×10−5 ± 1.2×10−5 | 4.1×10−5±0.4×10−5 | 0.119 | 0.367 |
| GLUT-4 | 161.7×10−5± 37.2×10−5 | 271.4×10−5±35.0×10−5 | 0.037 | 0.016 |
| Glucose Kinetics (by mFSIVGTT) b | PCOS (n=6) | Control (n=6) | ||
| Si (L min−1 m −1) | 1.67±0.39 | 3.43±0.81 | 0.079 | N/A |
| AIRg (mU L−1 m −1) | 709.35±13.51 | 702.33±123.50 | 0.969 | N/A |
| Di | 1140.33±280.48 | 1968.33±310.94 | 0.076 | N/A |
| Sg (min −1) | 140.2×10−5± 0.49.2 ×10−5 | 205.5×10−5± 51.4.2×10−5 | 0.380 | N/A |
| GEZI | 2.04 ×10−2±0.27 ×10−2 | 2.23 ×10−2 ±0.47×10−2 | 0.732 | N/A |
| BIE | 2.08 ×10−3±0.29 ×10−3 | 2.13 ×10−3 ±0.38×10−3 | 0.923 | N/A |
Values are means ± SE except for race and log-transformed data. P-values bolded and italicized are statistically significant.
Geometric means, the antilog of the log scale mean, is reported for log-transformed data
Assessment of mFSIVGTT parameters was performed in 6 PCOS women and 6 matched controls (see also supplemental Table 1).
To convert the plasma levels of glucose to mg/dL, insulin to μIU/m, Free Testosterone to pg/mL, Total Testosterone to ng/dL and DHEAS to ug/dL, divide the values by 0.0555, 7.175, 3.47, 0.0347 and 0.0271, respectively.14, 38
Abbreviations: AIRg is acute response of insulin to glucose; DHEAS is dehydroepiandrosterone sulfate; Di is disposition index; GLUT is glucose transporter; HOMA-IR is homeostasis model assessment of insulin resistance; HOMA-β% is homeostasis model assessment of β-cell function; mF-G is the modified Ferriman-Gallwey hirsutism score; mFSIVGTT is modified frequently sampled iv glucose tolerance test; N/A is ‘Not applicable’; Si is insulin sensitivity index; Sg is glucose effectiveness index; and WHR is the waist to hip ratio.