Figure 2.

Performance of clinical signs and CRP to discriminate infected and not infected neonates. Forest plot of odds ratio [95% CI] relative to each clinical sign for infection diagnosis is depicted (a). The squares represent odds ratio and bars indicate the 95% confidence interval (CI). ROC curve of both CRP and clinical model and best performing model combining tachycardia, capillary refill time >3 s, and hypotonia/lethargy are shown (b). AUC [95% CI] is calculated for the diagnosis of confirmed infection. Of note, these ROC curves and AUC are presented only as indicative since these parameters were used by the adjudication committee to classify patients and are thus partially biased.