Table 3.
Multivariate analysis results showing independent risk factors for overall survival in childhood acute lymphoblastic leukemia patients.
| Risk Factor | Crude HR (95% CI) | Adjusted HR (95% CI) | p Value |
|---|---|---|---|
| Age (years) | |||
| 1–9 | Reference | Reference | |
| <1 | 3.51 (1.79–6.89) | 3.05 (1.57–5.96) | 0.001 |
| ≥10 | 1.80 (1.29–2.52) | 1.64 (1.15–2.32) | 0.006 |
| Male sex | 1.11 (0.84–1.47) | 1.37 (1.05–1.79) | 0.021 |
| Immunophenotype | |||
| T-cell | Reference | Reference | |
| B-cell | 0.79 (0.55–1.15) | 1.37 (0.90–2.08) | 0.14 |
| FAB classification | 0.56 (0.31–1.01) | 0.85 (0.46–1.56) | 0.6 |
| Initial WBC count (×109/L) | |||
| <50 | Reference | Reference | |
| 50–<100 | 1.47 (0.97–2.23) | 1.59 (1.07–2.36) | 0.022 |
| ≥100–<200 | 2.45 (1.60–4.61) | 2.04 (1.33–3.14) | <0.001 |
| ≥200 | 3.04 (2.00–4.61) | 2.71 (1.74–4.21) | <0.001 |
| Early complication | 1.16 (0.79–1.71) | 0.88 (0.62–1.26) | 0.5 |
HR, hazard ratio; CI, confidence interval; FAB, French–American–British classification system; WBC, white blood cell.