Table 1.
Levels of lipid oxidation and total iron content in plasma or brainstem tissue of rats treated with ethidium bromide (EB) and/or propentofylline (PROP) for 7, 15, and 31 days. (* p < 0.05; ** p< 0.01).
| Control | EB | PROP | PROP + EB | |
|---|---|---|---|---|
| (i) Plasma | ||||
| TBARS (μmol·mL−1) | ||||
| 7 d | 13.1 ± 2.4 | 20.2 ± 2.4 (*) | 11.8 ± 0.9 | 15.4 ± 1.5 |
| 15 d | n.d. | 21.0 ± 2.9 (*) | 15.1 ± 2.6 | 19.7 ± 6.4 (*) |
| 31 d | n.d. | 10.8 ± 1.1 | 12.9 ± 2.6 | 12.4 ± 2.1 |
| (ii) Brainstem tissue | ||||
| TBARS (μmol·mg prot−1) | ||||
| 7 d | 0.64 ± 0.04 | 1.28 ± 0.27 (**) | 0.54 ± 0.06 | 0.72 ± 0.09 |
| 15 d | n.d. | 1.55 ± 0.28 (**) | 0.63 ± 0.05 | 0.88 ± 0.05 (*) |
| 31 d | n.d. | 1.06 ± 0.13 (**) | 0.52 ± 0.05 | 0.72 ± 0.07 |
| Iron content (μg·mg prot−1) | ||||
| 7 d | 88.2 ± 10.5 | 279.0 ± 60.6 (**) | 75.8 ± 24.7 | 214.5 ± 52.4 (**) |
| 15 d | n.d. | 413.4 ± 31.6 (**) | 433.3 ± 69.2 (**) | 409.7 ± 41.8 (**) |
| 31 d | n.d. | 285.3 ± 50.8 (**) | 261.0 ± 35.2 (**) | 279.6± 30.8 (**) |
n.d. = not determined.