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Impact of alterations in the placental environment associated with obesity and gestational diabetes mellitus—hyperglycemia, hyperinsulinemia and low oxygen—on the expression of serotonin-regulating genes in human first-trimester trophoblasts. SERT—serotonin transporter, TPH1—tryptophan hydroxylase 1, MAOA—monoamine oxidase A, Trp—tryptophan, 5-HIAA—5-hydroxyindolacetic acid, ↑ upregulation, ↓ downregulation. Created with Biorender.com.
