Table 1.
Counts, Crude Incidence Rates per 100 000 Population (95% CI), and Incidence Rate Ratios (95% CI) of (A) All GAS Infections (Invasive and Noninvasive), (B) Scarlet Fever, and (C) Invasive GAS Infections by LAIV Pilot and Nonpilot Areas and Influenza Seasons, 2010/2011 to 2016/2017 for Targeted Age Groups, 2 to 4 Years and 5 to 10 Years
| Season/Pilot Type | 2 to 4 Years | 5 to 10 Years | ||||
|---|---|---|---|---|---|---|
| Count | Crude Rate per 100 000 Population (95% CI) | Incidence Rate Ratio (95% CI) | Count | Crude Rate per 100 000 Population (95% CI) | Incidence Rate Ratio (95% CI) | |
| (A) GAS | ||||||
| 2010/2011 | ||||||
| Pilot | 72 | 53.0 (41.5–66.8) | 1.44 (1.13–1.84) | 96 | 38.0 (30.8–46.4) | 1.59 (1.29–1.96) |
| Nonpilot | 667 | 36.8 (34.1–39.7) | … | 784 | 23.9 (22.3–25.7) | … |
| 2011/2012 | ||||||
| Pilot | 78 | 56.7 (44.8–70.8) | 1.48 (1.17–1.87) | 119 | 46.7 (38.7–55.9) | 1.89 (1.56–2.30) |
| Nonpilot | 707 | 38.4 (35.6–41.3) | … | 819 | 24.7 (23–26.4) | … |
| 2012/2013 | ||||||
| Pilot | 91 | 65.3 (52.6–80.2) | 1.05 (0.85–1.29) | 108 | 41.6 (34.2–50.3) | 1.24 (1.01–1.50) |
| Nonpilot | 1170 | 62.5 (58.9–66.1) | … | 1144 | 33.7 (31.8–35.7) | … |
| 2013/2014 | ||||||
| Pilot | 107 | 75.9 (62.2–91.8) | 0.97 (0.80–1.18) | 146 | 54.7 (46.1–64.3) | 0.98 (0.83–1.16) |
| Nonpilot | 1481 | 78.1 (74.2–82.2) | … | 1952 | 55.7 (53.2–58.2) | … |
| 2014/2015 | ||||||
| Pilot | 91 | 63.1 (50.8–77.5) | 0.65 (0.53–0.80) | 136 | 49.5 (41.5–58.5) | 0.87 (0.73–1.04) |
| Nonpilot | 1885 | 97.2 (92.8–101.7) | … | 2043 | 56.7 (54.3–59.2) | … |
| 2015/2016 | ||||||
| Pilot | 133 | 91.1 (76.3–108.0) | 0.83 (0.70–1.00) | 145 | 51.7 (43.6–60.8) | 0.84 (0.71–0.99) |
| Nonpilot | 2124 | 108.7 (104.1–113.4) | … | 2282 | 61.7 (59.2–64.3) | … |
| (B) Scarlet Fever | ||||||
| 2016/2017 | ||||||
| Pilot | 93 | 63.7 (51.4–78.0) | 0.72 (0.59–0.89) | 130 | 45.2 (37.8–53.7) | 0.79 (0.67–0.95) |
| Nonpilot | 1713 | 88.1 (84.0–92.4) | … | 2158 | 56.9 (54.5–59.4) | … |
| 2010/2011 | ||||||
| Pilot | 59 | 43.5 (33.1–56.1) | 0.85 (0.65–1.10) | 40 | 15.8 (11.3–21.6) | 0.73 (0.53–1.01) |
| Nonpilot | 931 | 51.4 (48.2–54.8) | … | 710 | 21.7 (20.1–23.3) | … |
| 2011/2012 | ||||||
| Pilot | 89 | 64.7 (52.0–79.7) | 1.22 (0.98–1.52) | 50 | 19.7 (14.6–25.9) | 0.78 (0.59–1.04) |
| Nonpilot | 976 | 53.0 (49.7–56.4) | … | 833 | 25.1 (23.4–26.9) | … |
| 2012/2013 | ||||||
| Pilot | 92 | 66.0 (53.2–81.0) | 0.78 (0.63–0.96) | 76 | 29.3 (23.1–36.7) | 0.72 (0.57–0.90) |
| Nonpilot | 1594 | 85.1 (81.0–89.4) | … | 1390 | 40.9 (38.8–43.2) | … |
| 2013/2014 | ||||||
| Pilot | 305 | 216.5 (192.8–242.2) | 1.05 (0.93–1.18) | 290 | 108.6 (96.4–121.8) | 1.10 (0.98–1.24) |
| Nonpilot | 3922 | 206.92 (200.5–213.5) | … | 3447 | 98.3 (95.1–101.7) | … |
| 2014/2015 | ||||||
| Pilot | 313 | 217.1 (193.7–242.5) | 0.74 (0.66–0.82) | 232 | 84.4 (73.9–96.0) | 0.71 (0.62–0.81) |
| Nonpilot | 5722 | 295.0 (287.4–302.7) | … | 4297 | 119.3 (115.7–122.9) | … |
| 2015/2016 | ||||||
| Pilot | 364 | 249.3 (224.4–276.3) | 0.79 (0.71–0.87) | 227 | 80.9 (70.7–92.1) | 0.60 (0.53–0.69) |
| Nonpilot | 6206 | 317.5 (309.6–325.5) | … | 4980 | 134.7 (131.0–138.5) | … |
| 2016/2017 | ||||||
| Pilot | 380 | 260.2 (234.7–287.7) | 1.04 (0.94–1.16) | 345 | 119.9 (107.6–133.3) | 1.15 (1.03–1.28) |
| Nonpilot | 4859 | 249.9 (243.0–257.1) | … | 3966 | 104.6 (101.4–107.9) | … |
| (C) iGAS | ||||||
| 2010/2011 | ||||||
| Pilot | 1 | 0.7 (0.0–4.1) | 0.29 (0.04–2.10) | 3 | 1.2 (0.2–3.5) | 1.56 (0.47–5.16) |
| Nonpilot | 46 | 2.5 (1.9–3.4) | … | 25 | 0.8 (0.5–1.0) | … |
| 2011/2012 | ||||||
| Pilot | 1 | 0.7 (0.0–4.1) | 0.45 (0.06–3.28) | 1 | 0.4 (0.0–2.2) | 0.59 (0.08–4.40) |
| Nonpilot | 30 | 1.6 (1.1–2.3) | … | 22 | 0.7 (0.4–1.0) | … |
| 2012/2013 | ||||||
| Pilot | 6 | 4.3 (1.6–9.4) | 2.12 (0.90–5.02) | 1 | 0.4 (0–2.2) | 0.30 (0.04–2.16) |
| Nonpilot | 38 | 2.0 (1.4–2.8) | … | 44 | 1.3 (0.9–1.7) | … |
| 2013/2014 | ||||||
| Pilot | 1 | 0.7 (0.0–4.0) | 0.36 (0.05–2.65) | 2 | 0.7 (0.1–2.7) | 0.82 (0.20–3.42) |
| Nonpilot | 37 | 2.0 (1.4–2.7) | … | 32 | 0.9 (0.6–1.3) | … |
| 2014/2015 | ||||||
| Pilot | 0 | 0.0 (0.0–2.6) | — | 3 | 1.1 (0.2–3.2) | 0.91 (0.28–2.95) |
| Nonpilot | 54 | 2.8 (2.1–3.6) | … | 43 | 1.2 (0.9–1.6) | … |
| 2015/2016 | ||||||
| Pilot | 5 | 3.4 (1.1–8.0) | 0.92 (0.37–2.27) | 2 | 0.7 (0.1–2.6) | 0.45 (0.11–1.83) |
| Nonpilot | 73 | 3.7 (2.9–4.7) | … | 59 | 1.6 (1.2–2.1) | … |
| 2016/2017 | ||||||
| Pilot | 3 | 2.1 (0.4–6.0) | 0.71 (0.22–2.28) | 3 | 1.0 (0.2–3.1) | 1.24 (0.38–4.04) |
| Nonpilot | 56 | 2.9 (2.2–3.7) | … | 32 | 0.8 (0.6–1.2) | … |
Significant IRRs with P values <.05 are highlighted in bold.
Abbreviations: GAS, group A Streptococcus; iGAS, invasive group A Streptococcus; IRR, incidence rate ratio.