Table 4.

Summary of low-dose naltrexone’s therapeutic benefits in non-arthritic diseases.

Disease	Characteristics of the Study	LDN Benefits
Fibromyalgia	LDN doses of 3.88 mg or 5.40 mg were used.	Reduces pain intensity and quality
Multiple sclerosis	LDN dose of 4.5 mg was used in one study. In another study, inhibitory peptides were indirectly measured as a way of assessing efficacy.	Reduces suppression of lymphocytes and improves quality of life
Crohn’s disease	LDN dosage of 4.5 mg naltrexone/day.	Wound healing, minimal adverse effects, improved symptoms
Depression and anxiety	Small-scale studies based on subjective assessments for patients with treatment regimens supplemented with 1mg LDN (bid).	Decreased levels of depression and anxiety