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. 2023 Jun 20;11(6):1771. doi: 10.3390/biomedicines11061771

Figure 2.

Figure 2

The effect induced by Corylus avellana gemmotherapy extract on reduction of collagen deposition in fibrotic livers of diabetic mice. (A) RT–PCR analysis of collagen 1 (Col 1) gene levels. Legend: Control, DF—liver fibrosis in diabetic mice; DFR—self-recovery of liver fibrosis (positive control) in diabetic mice; DCA—Corylus avellana treatment of liver fibrosis in diabetic mice; *** p < 0.001 compared to control; ### p < 0.001 compared to DF; ^^^ p < 0.001 compared to DFR; (B) Collagen staining with Gomori’s trichrome kit. (a) Control group: no significant collagen deposition; (b) DF group: significant collagen deposition with pseudo-lobular separation (arrows); (c) DFR group: aspect almost similar to the LF-DIA group (arrows); (d) DCA less collagen deposition (isolated islands) compared to DF and DFR (arrows).