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. 2023 Jun 20;11(6):1771. doi: 10.3390/biomedicines11061771

Figure 5.

Figure 5

Effects of Corylus avellana gemmotherapy buds extract on tissue inhibitors of metalloproteinase (TIMP)-1/matrix metalloproteinase (MMP) pathway regulation. RT–PCR analysis of MMP1 (A), Timp-1 (B), MMP2 (C), MMP3 (D), MMP9 (E) gene expression levels. (F) Effects of on MMPs expression and enzymatic activity. (a) Images of gelatin zymography (pro-MMP-2, MMP-2, and MMP-9); (b) enzymatic activity of the metalloproteinases pro-MMP-2, MMP-2, and MMP-9, as well as (c) profile of MMP-2 and MMP-9 blots; (d) the expression of metalloproteinases MMP-2 and MMP-9 obtained following in vivo treatment of CA gemmotherapy extract. Legend: Control; DF—liver fibrosis in diabetic mice; DFR—self-recovery of liver fibrosis (positive control) in diabetic mice; DCA—Corylus avellana treatment of liver fibrosis in diabetic mice; *** p < 0.001 compared to control; * p < 0.05 compared to control; ** p < 0.01 compared to control; ### p < 0.001; ## p < 0.01; ^^^ p < 0.001 compared to DFR; ^ p < 0.05 compared to DFR.