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. 2023 Jun 19;15(12):3241. doi: 10.3390/cancers15123241

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

LIN28B transcriptional dynamics and let-7 functional antagonism in glioma. NFYA and c-Myc drive the transcription of LIN28B-TST and LIN28B-WT, respectively. Meanwhile, IMP2 blocks function of let-7-loaded RISC to derepress let-7 target oncogenes, thereby recapitulating the cellular phenotype induced by let-7-dependent LIN28A/B function. LIN28B-TST, LIN28B tumor-specific transcript. LIN28B-WT, LIN28B wild-type transcript. ONC, oncogene. Grey double helix, DNA. Blue single helix, mRNA. Orange two-subunit structure, ribosome.