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Metabolic activities downstream of LIN28A. LIN28A stabilizes SNHG14, driving an STAU1- and UPF1-dependent pathway that downregulates IRF6 expression. This derepresses IRF6-silenced genes PKM2 and GLUT1, resulting in an upregulation of aerobic glycolysis. Grey double helix, DNA. Blue single helix, mRNA. Green single helix, lncRNA. Orange two-subunit structure, ribosome. Pink box, programming.
