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Potential mechanisms regulating LIN28B nucleolar localization in glioma and cytoplasmic sequestration in glioma. K-RAS drives PKCβ-mediated LIN28B phosphorylation, facilitating its nucleolar translocation. Meanwhile, cell density dephosphorylates NF2, enhancing its association with LIN28B to result in cytoplasmic sequestration. Each mechanism must be verified in glioma.
