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CircRNAs participate in the liver fibrosis process. CircRNAs, such as CircUbe2k, CircPWWP2A, and CircRNA-4099 promote the activation of HSCs in normal liver tissues, generate pro-fibrosis factors such as α-SMA and Col1α1, and ultimately promote the development of liver fibrosis; CircRNAs, such as CircCREBBP, CircFBXW4, and CircPSD3 inhibit the activation of HSCs, reduce the production of pro-fibrosis factors such as α-SMA and Col1α1, and eventually inhibit liver fibrosis.
