Skip to main content
. 2023 Jun 10;13(6):939. doi: 10.3390/brainsci13060939

Figure 7.

Figure 7

HS mediates anti-inflammatory function by inhibiting the ROS-NLRP3 inflammasome pathway. (A) The viability of BV2 cells after LPS treatment was detected using CCK-8 at 0 h, 3 h, 6 h, 9 h, and 12 h. N = 5 per group, * p < 0.05. (B) Cell viability of BV2 cells (N = 5 per group) and (C) the ROS level in the Sham, LPS, LPS + H, LPS + NAC, and LPS + H + NAC groups. * p < 0.001 (LPS group vs. Sham group), # p < 0.001 (LPS + H group vs. LPS group), ˆ p < 0.001 (LPS + NAC group vs. LPS group), & p < 0.001 (LPS + H + NAC group vs. LPS + NAC group), N = 6 per group. (D) DCFH-DA staining (N = 5 per group). (E–H) Protein levels of NLRP3, Caspase-1 (P20), and cleaved IL-1β in the Sham, LPS, LPS + H, LPS + NAC, and LPS + H + NAC groups. * p <0.001 (LPS group vs. Sham group), # p < 0.05 or ## p < 0.001 (LPS + H group vs. LPS group), ˆ p < 0.05 or ˆˆ p < 0.01 or ˆˆˆ p < 0.001 (LPS + NAC group vs. LPS group), & p < 0.05 or && p < 0.01 (LPS + H + NAC group vs. LPS + NAC group), N = 4 per group.