Table 5.
Comparison of CRP detection methods based on different technologies.
| Detection Method | Sample Type | Sample Size | Test Time | Detection Probe | Detection Range | Limit of Detection | Ref. |
|---|---|---|---|---|---|---|---|
| Electrochemistry (DPV) | CRP antigen | - | 60 min | Antibody | 0.01–1000 pg/mL | 5.0 pg/mL | [59] |
| Electrochemistry (SWV) | Serum | - | 90 min | Aptamer | 1–125 ng/mL | 0.0017 ng/mL | [60] |
| SPR | Serum | - | 15 min | Antibody | 0.006–70 μg/mL | 0.009 μg/mL | [61] |
| Colorimetric immunoassay | CRP antigen | 30 μL | 5 min | Aptamer | 0.889–20.7 μg/mL | 1.2 μg/mL | [62] |
| Colorimetric immunoassay | CRP antigen | 100 μL | 30 min (pre-process) | Antibody | 10–5000 ng/mL | 100 ng/mL | [63] |
| SAW (Rayleigh wave) |
CRP antigen | 50 μL | 10 min | Antibody | 0.1–1000 μg/mL | 0.1 μg/mL | [64] |
| QCM | Serum | - | - | Antibody | 0.01–1000 ng/mL | - | [65] |
| SH-SAW | Finger blood | 5 μL | 3 min | Antibody | 2–120 μg/mL | 0.39 μg/mL | This paper |
| Serum | - | <10 ng/mL |
Differential pulse voltammetry (DPV); Square wave voltammetry (SWV); Surface plasmon resonance (SPR).