Table 4.
Estimated associations of metabolic subtypes A vs. B (referent) with progression-free survival via Cox models among the full HNSCC population and stratified by smoking status.
| HR | 95% CI | p Value | |
|---|---|---|---|
| Full Population (Nevents = 62) | |||
| Unadjusted model | 1.62 | (0.98, 2.67) | 0.06 |
| Age, sex, HPV, smoking adjusted model | 1.65 | (0.99, 2.75) | 0.06 |
| Fully adjusted model a | 1.70 | (0.93, 3.11) | 0.08 |
| Among Ever Smokers (Nevents = 47) | |||
| Unadjusted model | 2.06 | (1.14, 3.71) | 0.02 |
| Age, sex, HPV adjusted model | 2.13 | (1.17, 3.89) | 0.01 |
| Fully adjusted model a | 2.11 | (1.03, 4.32) | 0.04 |
| Among Never Smokers (Nevents = 15) | |||
| Unadjusted model | 1.00 | (0.35, 2.80) | 0.99 |
| Age, sex, HPV adjusted model | 0.80 | (0.27, 2.37) | 0.68 |
| Fully adjusted model a | 0.48 | (0.08, 3.03) | 0.44 |
a Further adjusted for race, body mass index, alcohol history, marital status, tumor site and stage, treatment, Eastern Cooperative Oncology Group (ECOG) performance, gastronomy tube, prior comorbidities, albumin, hemoglobin, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio; 40 subjects (25 ever and 15 never smokers), including 5 events (4 ever and 2 never smokers), were removed due to missing covariates. HNSCC = head and neck cancer squamous cell carcinoma, HR = hazard ratio, CI = confidence interval, HPV = human papillomavirus.