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. 2023 Jun 8;15(12):3112. doi: 10.3390/cancers15123112

Figure 4.

Figure 4

Epigenetic pretreatment causes a decrease in adhesion of MV4;11 cells to endothelial, stromal, and MSCs in multicell coculture and in MaxGel-coated wells. (A) MV4;11 cells were pretreated with 1 μM azacitidine and 1 nM panobinostat for 48 h, then stained and cultured for 4 h when plated onto stromal, MSCs, and endothelial cells in multicell coculture to determine if adhesion is impacted by epigenetic modifiers. The control is the percentage of bound untreated MV4;11 cells with respect to the input. (B) MV4;11 cells were plated in MaxGel-coated wells diluted in 1:100 DMEM media. Treatment adhesion was normalized and compared to input wells without PBS wash. Error bars display the SD from the mean of three independent experiments in duplicate. Each black dot represents individual value. *** p < 0.001.