Table 1.

Skin toxicity grading [26].

Adverse Reaction	Grace 1	Grade 2	Grade 3	Life-Threatening Reactions
Maculopapular rash	Macules/papules covering\10% BSA with or without symptoms (e.g., pruritus, burning, tightness)	Macules/papules covering 10–30% BSA with or without symptoms (e.g., pruritus, burning, tightness)	Macules/papules covering 30% BSA with or without associated symptoms; limiting self-care activities	-
Pruritus	Mild or localized; topical intervention indicated	Intense or widespread; intermittent; skin changes from scratching (e.g., edema, papulation, excoriations, lichenification, oozing/crusts); oral intervention indicated	Intense or widespread; constant; limiting self-care activities or sleep; oral corticosteroid or immunosuppressive therapy indicated