Figure 12.

Immunological landscape in CRC tumours according to high and low B7H3 expression. analyses received from CAMOIP based on TCGA-COAD dataset. (A) Comparison of immune cells infiltration scores estimated by CIBERSORT algorithm between B7H3 high- and B7H3 low-expression tumours. (B) Immune-related scores in CRC tumours with upregulated and downregulated B7H3 expression * p < 0.05, ** p < 0.01, and *** p < 0.001. **** p < 0.0001, ns = not significant (C) Expression of CD163 (M2 macrophage marker) in B7H3 low and high expression groups. (D,E) Differences in MANTIS score between groups with high and low expression of B7H3 and CD274 (PD-L1). MANTIS score predicts tumour MSI status by assuming values from 0 (entirely MSS) to 2.0 (entirely MSI). The greater the MANTIS score, the more likely tumour MSI status.