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. 2023 Jun 19;13(6):1013. doi: 10.3390/biom13061013

Figure 4.

Figure 4

Effect of 5-HT on mitochondrial ROS production and ROS on cell shortening. (A) Rat mitochondrial ROS production. Mitochondria from rat hearts were isolated and ROS production was measured in the presence of complex I substrate, with 5-HT (concentration 1–100 µM) and/or clorgyline (1 µM) and 5-HT. Data are full ranges (whiskers) with median and 25 and 75% quartiles (boxes). *; p < 0.05 vs. control; Kruskal–Wallis test with Bonferroni (correction for multiple testing) post hoc analysis; n = 4–8. (B) Effect of Tempol (1 mmol/L) on cell shortening. Data are full ranges (whiskers) with median and 25 and 75% quartiles (boxes). *; p = 0.000192 vs. control; Student’s t-test; n = 54.