Figure 2.

Classification of PiD as a unique neuropathological entity in the intersection of the FTLD and Primary Tauopathy disease spectra. Due to its neuropathological signature, PiD falls under the FTLD spectrum of disease and more specifically the FTLD-Tau clade, as well as the primary tauopathy disease umbrella which is further divided into three categories (3R tauopathy, 4R tauopathy, and 3R+4R tauopathy) based on which form of the tau protein accumulates in the aggregates characterizing each disease. BIBD = basophilic inclusion body disease, NFID = neuronal intermediate filament inclusion disease, FTLD-17 = FTLD-Tau caused by mutations on the tau encoding gene, MAPT, on chromosome 17, GGT = globular glial tauopathy, AGD = argyrophilic grain disease, CTE = chronic traumatic encephalopathy. [Figure created via BioRender.com].