Table 4.

Polyphenols that make tumor cells more sensitive to chemotherapeutic drugs (adapted from ref. [107]).

Polyphenol	Chemotherapy Drug	Result
Apigenin	Cisplatin	Inhibits growth of drug-resistant colon cancer cells while inducing autophagy
Resveratrol	Cisplatin	Induces autophagic and apoptotic death in drug-resistant oral cancer cells
Curcumin	5-Fluorouracil	Exerts synergistic effects with the chemotherapeutic drug by impairing AMPK/ULK1-dependent autophagy
EGCG	Cisplatin	Increases sensitivity of CAR cells, apoptosis, and autophagy by AKT/STAT3 pathway
Curcumin	Docetaxel	Leads to induction of apoptosis and autophagy through PI3K/AKT/mTOR pathway
Resveratrol	Gefitinib	Overcomes drug resistance while inducing apoptosis, autophagy, and senescence in PC9/G NSCLC cells
Curcumin	Gefitinib	Enhances the efficacy of the drug and overcomes EGFR-TKI resistance in NSCLC patients with wild-type EGFR and/or KRAS mutation