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. 2023 Jun 8;13(6):929. doi: 10.3390/brainsci13060929

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Potential therapeutic effects of plants and plant-derived compounds on obesity-induced cognitive impairment. Various mechanisms through which plants and isolated compounds can improve cognitive function in obese individuals include attenuation of neuroinflammation, reduction in acetylcholinesterase (AChE) expression, improvement of central and peripheral insulin resistance, enhancement of neurogenesis and neuroprotection, and modulation of the synthesis and release of cognition-associated neurotransmitters. The figure also depicts the improvement of spatial cognition, as measured by the Morris water maze, in an obese rat supplemented with plant or plant-derived compounds. Figure created with BioRender.com (accessed on 17 May 2023).