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. 2023 Jun 16;11(6):1735. doi: 10.3390/biomedicines11061735

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Low in vitro cytokine induction post-mRNA-LNP administration. Induction of interferon-gamma-induced protein 10 kDa, CXCL10 (IP-10), macrophage inflammatory protein-1 beta (MIP-1β), and monocyte chemoattractant protein-1 (MCP-1), 24 h after application of dose range from 0.01 up to 1.5 µg/well of four optimized LNP-ASL mRNAs was tested in human peripheral blood mononuclear cells (PBMCs) using Meso Scale Discovery. Control levels of cytokines in PBS-transfected cells are represented using a green dashed line. Legend refers to all three graphs in the figure. Data show mean ± standard deviation (SD) from two replicates (N = 2).