Table 1.

Deregulated miRNAs in PCa and other cancers.

MiRNAs	Regulation in PCa	MiRNA Target Genes and Regulated Pathways in PCa	References
let-7/let-7a	Downregulation	CCR7 MAPK/EMT signaling pathways	[35,36]
miR-1	Downregulation	MET, KRAS c-Met/AKT/mTOR signaling	[38,39]
miR-29b	Downregulation	AKT2, MCL1	[42,44]
miR-30c	Downregulation	ASF/SF2, E2F7	[40,41]
miR-34a	Downregulation	SIRT1, E2F1, CDK6, Cyclin D1, E2F3, BCL2	[55,57,58]
miR-99b	Downregulation	MTOR, SMARCA5, SMARCD1, PSA, AR	[59,60,62,100]
miR-133a	Downregulation	FUS, AR, EGFR, FGFR1, IGF1R, and MET	[67,68,101]
miR-134	Downregulation	EGFR, cyclin D/cyclin D2/CDK4, KRAS, EGFR, POGLUT1, STAT5B, KRAS, NANOG, HNF4A, EGFR, ITGB1, FOXM1, HER2, PIK3CA, ITGB1, POGLUT1	[69,70,102]
miR-205	Downregulation	AR, MAPK	[73]
miR-221	Downregulation Upregulation	SOCS1, BMI1 Ras/Raf/MEK/ERK signaling HECTD2, RAB1A, AR reprograming in CRPC	[74,75,76,77]
miR-375	Downregulation	QKI5, CD44	[78,79,80]
miR-21	Upregulation	PTEN, RECK, MARCKS, PDCD4, TPM1 JAK/STAT3 cascades	[82,83,103]
miR-96	Upregulation	FOXO1, MTSS1, EGFR, MTOR, ATG7	[69,104,105]
miR-106b	Upregulation	TEN, AKT, CNN1, LARP4B, RUNX3, DAB2, DLC1, FOG2, REST1, FUT6, ALEX1 and BTG3, CDKN1A (p21 gene), E2F1, Ki67, MMP2, CD44, and SMAD2	[86]
miR-125b	Upregulation	BAK1, TP53, PUMA	[88,106]
miR-141	Upregulation	AKT and Rb/E2F signaling	[89,107]
miR-145	Upregulation	SP1, CDK6, AKAP12, RAD51, MCL1, PAR4, PARP1	[90]
miR-182	Upregulation	NDRG1, GNA13, BRCA1, PDCD4, ST6GALNAC5	[91]
miR-200c	Upregulation	BRD7, BMI1 EMT, AKT signaling pathways	[93,94,95]
miR-222	Upregulation	CDKN1B, CDKN1C	[97]