Table 2.
MiRNAs involved in treatment resistance. ↓: downregulated in PCa; ↑: upregulated in PCa; ADT: androgen deprivation therapy; Enz: enzalutamide; DCT: docetaxel.
| MiRNA (Up or Down in PCa) | Target Gene(s) | Treatment Resistance | References |
|---|---|---|---|
| miR-148a ↓ | MSK1 | ADT resistance | [122] |
| miR-125b ↓ | TP53, PUMA, BAK11 | ADT resistance | [88] |
| miR-216a ↑ | PTEN, TGFBR2 | ADT resistance | [124] |
| miR-194 ↓ | FOXA1 | Enz resistance | [125] |
| miR-27a, miR-101 ↓ | NR2F2 | Enz resistance | [126] |
| miR-30c-1/miR-103a-2 ↑ | AR-V7 | Enz resistance | [121] |
| miR-644a ↓ | MYC, BCLXL, BCL2, AKT, IGF1R | Enz resistance | [125] |
| miR-221 ↓ | ERG | Androgen-independent | [130,131] |
| miR-145 ↓ | ERG | Enz resistance | [132] |
| miR-187 ↓, miR-182 ↑ | TMPRSS2-ERG | Enz resistance | [133] |
| miR-143 ↓ | IGF1R, IRS1 | DCT resistance | [135] |
| miR-183 | DCT resistance | [147] | |
| miR-21 ↑ | PDCD4 | DCT resistance | [137,138] |
| miR-205, miR-31 ↓ | BCLW, E2F6 | DCT resistance | [139,140] |
| miR-195 ↓ | CUL | DCT resistance | [142] |
| miR-223-3p ↑ | FOXO3 | DCT resistance | [143] |
| miR-4735-3p ↓ | MEKK1 | DCT resistance | [144] |
| miR-19b-3p, miR-26b-5p, miR-374b-5p ↓ | LARP1, CCND1 | Paclitaxel resistance | [145] |
| miR-15a, miR-16 ↓ | CCND1, WNT3A | Cisplatin resistance | [146] |
| miR-128 ↓ | ZEB1, BIM1 | Cisplatin resistance | [148,149] |
| miR-205 ↓ | RAB27A, LAMP3 | Cisplatin resistance | [32] |