Figure 3.

Single-cell transcriptomic analysis of ER signaling in 5 ER+ breast cancer PDX models. (A) UMAP of cells from 5 ER+ orthotopic PDX models. Colors represent each model. (B) Phases of the cell cycle overlayed onto the UMAP of each of the PDX models and the quantification of percentage of each model in the phases of the cell cycle. (C) ESR1, PGR, and ERBB2 expression in respective populations. (D) Violin plots representing expression of ESR1 and target genes of ER. (E) Cell-cycle-related transcript expression in ER+ PDX models. (F) FGFR1 and TACC1 expression in all models, particularly in BCM-15057. (G) Gatza_2017_overexpressed_PIK3CA signature score for single cells from 5 ER+ PDX models.