Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Activation mechanisms of PLC. PLCβ isozymes are activated by Gαq, Gβγ, and Rac. PLCγ isoforms are activated by RTKs. PLCδ activity can be stimulated by Ca2+ within the physiological range through the activation of the other PLC isozymes or influx of Ca2+ through calcium channels. PLCε can be activated by GPCRs and RTKs as well as by small GTPases. PLCζ and PLCη are highly sensitive to Ca2+ and respond to small elevations in intracellular Ca2+ levels. PLCη is also activated by GPCR.
