Figure 3.

One proposed effect of IP6 on bone metabolism. IP6 can modulate the proliferation of osteoclasts (osteoclastogenesis), thereby controlling the rate of bone resorption. In the absence of IP6, the rate of osteoclastogenesis increases (as indicated by the upward arrows), resulting in increased bone resorption and increased serum calcium and inorganic phosphate. In the presence of sufficient IP6, decreased osteoclastogenesis and bone resorption (as indicated by the downward arrows) are observed as indicated by the downward arrows. This may be significant in persons who have pre-existing bone pathologies.