Table 7.
Germline Testing Results and Timeliness Pre- and Post-Nurse Navigation.
| Pre NN | Post NN | p-Value * | |
| n = 34 | n = 44 | ||
| Physician recommended germline testing, n (%) | 1.00 | ||
| Yes | 31 (91.2) | 41 (93.2) | |
| No | 3 (8.8) | 3 (6.8) | |
| Germline testing completed, n (%) | 0.008 | ||
| Yes | 27 (79.4) | 22 (50) | |
| No | 7 (20.6) | 22 (50) | |
| n = 27 | n = 22 | ||
| Germline testing results, n (%) | 0.31 | ||
| Negative/VUS | 23 (85.2) | 16 (72.7) | |
| Positive | 4 (14.8) | 6 (27.3) | |
| Germline BRCA or HRD mutated ** | 1.00 | ||
| Yes | 4 (14.8) | 4 (18.2) | |
| No | 23 (85.2) | 18 (81.8) | |
| n = 4 | n = 6 | ||
| Positive germline mutation results, n (%) | 0.30 | ||
| ATM | 1 (25) | 0 | |
| BRCA1 | 3 (75) | 1 (16.7) | |
| BRCA2 | 0 | 2 (33.3) | |
| NF1 | 0 | 1 (16.7) | |
| PALB2 | 0 | 1 (16.7) | |
| WRN | 0 | 1 (16.7) | |
| n = 6 | n = 4 | ||
| Germline VUS, n (%) | 0.22 | ||
| ATM VUS | 0 | 2 (50) | |
| CDKN1B VUS | 1 (16.7) | 0 | |
| MSH6 VUS | 1 (16.7) | 0 | |
| PMS2 VUS | 0 | 1 (25) | |
| DICER1 VUS | 2 (33.3) | 0 | |
| PALB2 VUS | 1 (16.7) | 0 | |
| POLD1 VUS | 1 (16.7) | 0 | |
| SMARCA4 VUS | 0 | 1 (25) | |
| Time Interval Date physician recommended genetics to germline test results, mean number days (95% CI) |
n = 19 135.4 (88.4–182.5) |
n = 16 69.1 (34.8–103.5) |
0.03 |
| Date physician recommended genetics to genetic counseling, mean number days (95% CI) |
n = 19 82.5 (43.4–121.7) |
n = 18 48.4 (17.0–79.8) |
0.16 |
| Date of genetic counseling to germline test results, mean number days (95% CI) |
n = 19 52.9 (12.3–93.5) |
n = 15 24.2 (11.9–36.5) |
0.21 |
* p-values were calculated using Chi-square or Fisher exact test; ** HRD genes: ATM, BARD1, BRIP1, CHEK1, CHEK2, FANCA, FANCC, MRE11A, NBS1, PALB2, RAD50, RAD51, RAD51B, RAD51C, RAD52, RAD54L.